![]() ![]() It has been clearly understood that the gut inhabitants and their proper balance is the foremost criteria that determines healthy status, particularly in terms of metabolic disorders ( Wang et al., 2015). ![]() diarrhea, inflammatory bowel disease, obesity, type 2 diabetes, cardiovascular disease, cancer etc. Several reference probiotic strains have been shown to play a potential role in management of several clinical scenarios viz. ( Majeed et al., 2016) along with few strains of Saccharomyces spp. Other preferred bacteria include strains of Enterococcus, Streptococcus and Bacillus spp. ![]() are the two globally recognized groups of bacteria that are being consumed for their potential health benefits. ![]() Among the large number of suggested options, probiotic therapy seems to be the most viable one, with long history of consumption and assured safety. The consumer awareness, search for alternate, safe and cost-effective treatments, and concern of developing antibiotic resistance has compelled researchers to find an alternate to ongoing therapeutic regimes, mainly dependent over antibiotics. Probiotics have also found application in animal feed for prevention of gastrointestinal infections, with extensive use in the poultry and aquaculture industries ( Hong et al., 2005). Different dairy/functional foods/dietary supplements and pharma formulations harbor probiotic strains, intended for various health benefits in humans. Probiotic formulations are being developed and standardized for both human and animal consumption. Probiotics are live microorganisms, which when administered in adequate amounts confer health benefits to the host ( FAO/WHO, 2002). The term Probiotics, taken as an un-challenged synonym to beneficial microbes, has gained popularity over the years and has found application in several general health and clinical scenarios. The interest in the field of beneficial microbes has emerged multiple folds since its inception by the Russian Noble laureate, Elie Metchnikoff. Moreover, the growing need to evaluate the safety of individual Bacillus strains as well as species on a case by case basis and necessity of more profound analysis for the selection and identification of Bacillus probiotic candidates are also taken into consideration. and presents an overview of the proposed health benefits, including application in food and pharmaceutical industry. This review highlights the probiotic candidature of spore forming Bacillus spp. and their substantiation with those having GRAS status, to reach a consensus over the same. Hence, it’s important to clearly understand the phenotypic and genotypic characteristics of selective beneficial Bacillus spp. had not gained much credential in general population, since the debate over probiotic vs pathogen tag of Bacillus in the research and production terrains is confusing consumers. Nonetheless, with proposed scientific evidences, commercial probiotic supplements, and functional foods comprising of Bacillus spp. Further, Bacillus strains also possess biotherapeutic potential which is connected with their ability to interact with the internal milieu of the host by producing variety of antimicrobial peptides and small extracellular effector molecules. Besides, bacilli are more stable during processing and storage of food and pharmaceutical preparations, making them more suitable candidate for health promoting formulations. are gaining interest in human health related functional food research coupled with their enhanced tolerance and survivability under hostile environment of gastrointestinal tract. The inherent ability of production of large number of secretory proteins, enzymes, antimicrobial compounds, vitamins, and carotenoids specifies the importance of bacilli in food chain. Spore-forming bacilli are being explored for the production and preservation of food for many centuries. 2Department of Dairy Microbiology, College of Dairy Science and Technology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.1Department of Dairy Science, Faculty of Agriculture, Cairo University, Giza, Egypt.Gulhane 2 Chetan Sharma 2 Harsh Panwar 2* ![]()
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